In an era where sexually transmitted infections (STIs) are on the rise among older Americans, immunocompromised patients undergoing biologic treatments face an even greater risk. This roundtable, led by Sagebrush Health, a non-profit dedicated to protecting vulnerable patients, enhancing continuity of care and reducing financial risk, delves into the complexities of providing essential sexual health education to this vulnerable group. We will explore the intersection of clinical care, education, and advocacy, emphasizing the unique challenges and opportunities in safeguarding the health of patients on immunosuppressive therapies. Join us to discuss innovative strategies, collaborative opportunities, and the critical role of healthcare providers in bridging the gap between clinical treatment and comprehensive patient education.