Immunoglobulin (Ig) therapy is a complex and multifaceted treatment that requires meticulous clinical management to ensure patient safety, minimize adverse effects, and optimize therapeutic outcomes. Clinicians must navigate a variety of factors, including product selection, dosing, administration techniques, hydration, and premedication strategies, to mitigate potential complications such as thromboembolic events, infusion reactions, and systemic or local adverse drug reactions. Tailoring Ig therapy to the individual patient involves addressing their unique risk factors and clinical needs through a range of mitigation pathways. These include adjusting the dose or dose interval, modifying the administration method, and switching to a different Ig product or route of administration. By employing these strategies, healthcare providers can create personalized care plans that not only enhance tolerability but also improve patient safety and overall treatment efficacy.