Where do we draw the line when the “right” decision isn’t clear—and the risks span patient harm, staff safety, and regulatory exposure? As home infusion expands into higher-acuity populations, clinicians and program leaders are increasingly forced to operate in these gray zones beyond standard guidelines. Through moderated, case-based discussion, panelists will work through real-world scenarios that highlight themes of patient selection and social risk, clinical appropriateness, and variability in regulatory and safety practices—prompting discussion on how organizations respond in the absence of clear guidance. Attendees will gain practical frameworks and peer-informed strategies to support consistent, defensible, and patient-centered decisions in complex home infusion cases