The quality and purity of compounded sterile preparations (CSPs) are significantly influenced by the cleanliness of the clean room environment and work surfaces. The most effective way to maintain the necessary levels of cleanliness and ensure a state of microbiological control is through regular cleaning and disinfecting of secondary engineering controls (SECs). This presentation will cover the recommended frequency and best practices for cleaning and disinfecting all surfaces in a sterile compounding clean room. Attendees are encouraged to bring any real-world cleaning issues or problems they have encountered for discussion.