Pediatric acute-onset neuropsychiatric syndrome (PANS) and PANDAS, a subset of PANS associated with strep, are autoimmune disorders that impact the pediatric population. The National Institute of Mental Health brought awareness to these disorders in the early 90s. Scientists today estimate that up to 1 in 200 children are impacted. This educational session will discuss the criteria for diagnosis, the pathogenic mechanism, and current treatment options, including IVIG. Interactive case studies will allow audience participation in diagnosing and treating these challenging cases.